New York University’s Center for Genomics and Systems Biology
Plant Systems Biology @ The Coruzzi Lab
From predictive network modeling to trait evolution
Plant Systems Biology
Our research in Plant Systems Biology resides in Pasteur’s Quadrant – the scientific space where investigations of basic processes aim ultimately to be beneficial to society. Our network inference studies in Arabidopsis have enabled us to predictively model and manipulate gene regulatory networks affecting Nitrogen-Use Efficiency (NUE), a trait with impact on the environment, energy and human nutrition. Our work in the model plant Arabidopsis bridges bench-to-field via commercial licensing agreements on the improvement of nitrogen use in crops. To further exploit plant genome diversity for practical gain, we have developed functional phylogenomic approaches to identify genes associated with the evolution of key agronomic traits, which has generated the largest genome-scale phylogeny of the seed plants. We have embodied the approaches and tools we have developed into software platforms to inspire and enable Systems Biology studies in Arabidopsis and several crop plants using VirtualPlant (www.virtualplant.org) and also in BigPlant v1.0 (http://nypg.bio.nyu.edu/bp/), a community resource and phylogenomic analysis of 150 seed plant genomes that enables researchers to explore the genomic origins of plant diversification across a wide range of species and questions in plant biology.
NYU’s Center for Genomics & Systems Biology
Our laboratory is located at NYU’s Center for Genomics and Systems Biology, a revolutionary 70,000 sq ft “hub of science” located at the very heart of the Washington Square campus. Beyond its original restored Greenwich Village façade are state-of-the art open “loft laboratories” and Core Facility where teams of biologists and computer scientists interact to unleash the extraordinary potential of Systems Biology.
Biologists and Computer Scientists
Our Systems Biology projects are the result of a highly successful collaboration between plant biologists and computer scientists in our lab and with colleagues at NYU Courant. Our plant phylogenomics studies involve a unique mix of plant biologists, systematists and computer scientists from NYU, NYBG, AMNH and CSHL – all working together in the New York Plant Genomics Consortium.
Our Institutional Collaborators
Our projects in Plant Systems Biology are the result of a close and highly successful collaboration between biologists and computer scientists. Our network modeling studies in Arabidopsis are performed in close collaboration with colleagues at NYU Courant Institute of Math & Computer Sciences. Our studies on phylogenomics that aim to identify the genetic origins of the seed plants is the result of collaborative research by the New York Plant Genomics Consortium that includes NYU’s Center for Genomics & Systems Biology, NYU Courant, New York Botanical Garden, American Museum of Natural History and Cold Spring Harbor Laboratory.