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The main goals of our research is to uncover biological regulatory mechanisms that control metabolic and regulatory networks in plants using a combination of genomic, bioinformatics and molecular-genetic approaches. Our lab has have two main areas of inquiry:
Overview: Our research is focused on identifying the underlying mechanisms responsible for the transcriptional regulation of metabolic regulatory networks in Arabidopsis. In particular, our studies relate to identifying gene networks whose expression is controlled by the intersection of light, carbon and nitrogen signals and to identify the regulatory pathways controlling them. We are taking a multidisciplinary approach to this problem by combining molecular-genetic, genomic, bioinformatic and systems biology approaches. Our bioinformatic work in Arabidopsis is done in collaboration with colleagues at NYU Courant Institute of Math & Computer Sciences. We are also using evolutionary and comparative genomic approaches to identifying biological regulatory mechanisms. In one proof-of-principle project we are using phylogenomic approaches to study the genomes of key nodes of seed plant evolution with the aim of identifying key genes associated with the evolution of seeds, a key agronomic trait in plants. This work is being done in NYU's Center for Comparative Functional Genomics as part of a NY Plant Genomic Consortium that includes NYU Biology, NYU Courant, NYBG, AMNH and CSHL. |